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      Cover image for Autism and the Environment: Challenges and Opportunities for Research, Workshop Proceedings
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      Autism and the Environment: Challenges and Opportunities for Research, Workshop Proceedings

      Forum on Neuroscience and Nervous System Disorders,Institute of Medicine

      Autism spectrum disorders (ASD) constitute a major public health problem, affecting one in every 150 children and their families. Unfortunately, there is little understanding of the causes of ASD, and…

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      Cover image for From Molecules to Minds: Challenges for the 21st Century: Workshop Summary
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      From Molecules to Minds: Challenges for the 21st Century: Workshop Summary

      The Institute of Medicine Forum on Neuroscience and Nervous System Disorders hosted the leading neuroscientists in the world, for a workshop titled ‘From Molecules to Minds: Challenges for the 21st…

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      Cover image for Neurodegeneration: Exploring Commonalities Across Diseases: Workshop Summary
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      Neurodegeneration: Exploring Commonalities Across Diseases: Workshop Summary

      Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Presents the summary of a workshop hosted by the Institute of Medicine\‘s (IOM\’s) Forum on Neuroscience and Nervous System Disorders in Spring 2012 to explore commonalities across neurodegenerative diseases such…

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      Cover image for Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary
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      Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary

      Forum on Neuroscience and Nervous System Disorders,Institute of Medicine

      Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders…

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      Cover image for Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships: Workshop Summary
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      Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships: Workshop Summary

      Forum on Neuroscience and Nervous System Disorders,Institute of Medicine

      Discusses the practical arenas in neuroscience in which biomarkers have the greatest impact. This title identifies biomarker targets that are being pursued and that could have the near-term impact on…

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      Cover image for Venture Philanthropy Strategies to Support Translational Research
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      Venture Philanthropy Strategies to Support Translational Research

      Forum on Neuroscience and Nervous System Disorders,Institute of Medicine

      Many voluntary health organizations fund translational research. An increasing number of these organizations are looking at venture philanthropy as a critical way to advance their missions of helping patients and…

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      Cover image for CNS Clinical Trials: Suicidality and Data Collection: Workshop Summary
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      CNS Clinical Trials: Suicidality and Data Collection: Workshop Summary

      Forum on Neuroscience and Nervous System Disorders

      The Food and Drug Administration (FDA) now requires that all clinical trials for drugs that affect the central nervous system–including psychiatric drugs–are assessed for whether that drug might cause suicidal…

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      Cover image for Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary
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      Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary

      Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that can…

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      Cover image for Improving and Accelerating Therapeutic Development for Nervous System Disorders: Workshop Summary
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      Improving and Accelerating Therapeutic Development for Nervous System Disorders: Workshop Summary

      Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine

      Presents the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system…

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      Cover image for Sex Differences and Implications for Translational Neuroscience Research: Workshop Summary
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      Sex Differences and Implications for Translational Neuroscience Research: Workshop Summary

      Forum on Neuroscience and Nervous System Disorders,Institute of Medicine

      Biological differences between the sexes influence not only individual health but also public health, biomedical research, and health care. The Institute of Medicine held a workshop March 8-9, 2010, to…

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      Cover image for Future Opportunities to Leverage the Alzheimer's Disease Neuroimaging Initiative: Workshop Summary
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      Future Opportunities to Leverage the Alzheimer’s Disease Neuroimaging Initiative: Workshop Summary

      Forum on Neuroscience and Nervous System Disorders,Institute of Medicine

      The project that is the subject of this report was approved by the Governing Board of the National Research Council … –T.p. verso.

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      Cover image for Alzheimer's Diagnostic Guideline Validation: Exploration of Next Steps: Workshop Summary
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      Alzheimer’s Diagnostic Guideline Validation: Exploration of Next Steps: Workshop Summary

      Forum on Neuroscience and Nervous Systems Disorders,Institute of Medicine

      Scientific advances during the last decade now indicate that Alzheimer’s disease is a continuous, progressive cognitive disease, most likely beginning many years before dementia is apparent. To discuss the next…

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      Cover image for Exploring the Adoption of Implantable Brain Stimulation into Standard of Care for Central Nervous System Disorders
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      Exploring the Adoption of Implantable Brain Stimulation into Standard of Care for Central Nervous System Disorders

      National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Forum on Neuroscience and Nervous System Disorders

      Implantable brain stimulation has had a profound impact on neuroscience research and the treatment of central nervous system disorders by allowing physicians to directly intervene in the pathological neural circuits…

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      Cover image for Non-Invasive Neuromodulation of the Central Nervous System: Opportunities and Challenges: Workshop Summary
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      Non-Invasive Neuromodulation of the Central Nervous System: Opportunities and Challenges: Workshop Summary

      National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Based on advances in biotechnology and neuroscience, non-invasive neuromodulation devices are poised to gain clinical importance in the coming years and to be of increasing interest to patients, clinicians,health systems…

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      Cover image for Developing a 21st Century Neuroscience Workforce: Workshop Summary
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      Developing a 21st Century Neuroscience Workforce: Workshop Summary

      Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      From its very beginning, neuroscience has been fundamentally interdisciplinary. As a result of rapid technological advances and the advent of large collaborative projects, however, neuroscience is expanding well beyond traditional…

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      Cover image for Financial Incentives to Encourage Development of Therapies That Address Unmet Medical Needs for Nervous System Disorders: Workshop Summary
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      Financial Incentives to Encourage Development of Therapies That Address Unmet Medical Needs for Nervous System Disorders: Workshop Summary

      Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation,Forum on Neuroscience and Nervous System Disorders

      The Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders, in collaboration with the IOM Forum on Drug Discovery, Development, and Translation, convened a workshop on January 20-21…

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      Cover image for Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression: Workshop Summary
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      Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression: Workshop Summary

      National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Summary of Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression: a workshop, held on February 24, 2015 in Washington, D.C.

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      Cover image for Assessing the Impact of Applications of Digital Health Records on Alzheimer's Disease Research: Workshop Summary
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      Assessing the Impact of Applications of Digital Health Records on Alzheimer’s Disease Research: Workshop Summary

      National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      "The national academies of sciences-engineering-medicine"--Cover.

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      Cover image for Toward a Common Research Agenda in Infection-Associated Chronic Illnesses
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      Toward a Common Research Agenda in Infection-Associated Chronic Illnesses

      National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Board on Global Health, Forum on Neuroscience and Nervous System Disorders, Forum on Microbial Threats

      The National Academies Forum on Microbial Threats and Forum on Neuroscience and Nervous System Disorders hosted a hybrid public workshop in June 2023 to explore opportunities to advance research and…

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      Cover image for Strengthening Human Resources Through Development of Candidate Core Competencies for Mental, Neurological, and Substance Use Disorders in Sub-Saharan Africa: Workshop Summary
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      Strengthening Human Resources Through Development of Candidate Core Competencies for Mental, Neurological, and Substance Use Disorders in Sub-Saharan Africa: Workshop Summary

      Institute of Medicine,Board on Health Sciences Policy,African Science Academy Development Initiative,Forum on Neuroscience and Nervous System Disorders

      An international workshop was convened in 2009, by the S Institute of Medicine (IOM) Forum on Neuroscience and Nervous Systems Disorders and the Uganda National Academy of Sciences (UNAS) Forum…

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      Cover image for Improving Access to Essential Medicines for Mental, Neurological, and Substance Use Disorders in Sub-Saharan Africa: Workshop Summary
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      Improving Access to Essential Medicines for Mental, Neurological, and Substance Use Disorders in Sub-Saharan Africa: Workshop Summary

      Institute of Medicine,Board on Global Health,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      In 2011 the Grand Challenges in Global Mental Health initiative identified priorities that have the potential to make a significant impact on the lives of people with mental, neurological, and…

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      Cover image for Adult Attention-Deficit/Hyperactivity Disorder
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      Adult Attention-Deficit/Hyperactivity Disorder

      National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Forum on Neuroscience and Nervous System Disorders, Forum on Drug Discovery, Development, and Translation

      Attention deficit/hyperactivity disorder (ADHD) diagnosis and treatment among adults has increased over the past decade in the U.S. and globally. Evidence suggests adults with ADHD may be more likely to…

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      Cover image for Mental, Neurological, and Substance Use Disorders in Sub-Saharan Africa: Reducing the Treatment Gap, Improving Quality of Care: Workshop Summary
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      Mental, Neurological, and Substance Use Disorders in Sub-Saharan Africa: Reducing the Treatment Gap, Improving Quality of Care: Workshop Summary

      Forum on Neuroscience and Nervous System Disorders,Institute of Medicine,Forum on Health and Nutrition,Uganda Academy of Sciences

      Millions of people in sub-Saharan Africa suffer from mental, neurological, and substance use (MNS) disorders, and most do not have the resources to obtain treatment. The Uganda National Academy of…

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      Cover image for Providing Sustainable Mental and Neurological Health Care in Ghana and Kenya: Workshop Summary
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      Providing Sustainable Mental and Neurological Health Care in Ghana and Kenya: Workshop Summary

      National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Global Health,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Providing Sustainable Mental Health Care in Kenya: a Workshop, Villa Rosa Kempinski, Chiromo Road, Nairobi, Kenya, January 13-14, 2015 –Page 75.

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      Cover image for Exploring Sleep Disturbance in Central Nervous System Disorders
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      Exploring Sleep Disturbance in Central Nervous System Disorders

      National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Forum on Neuroscience and Nervous System Disorders

      Chronic sleep disorders affect one in five Americans, and sleep deprivation costs significant U.S. GDP loss annually. Despite the indisputable biological importance of sleep, much remains unknown about underlying mechanisms.

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      Cover image for Harnessing Mobile Devices for Nervous System Disorders: Proceedings of a Workshop
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      Harnessing Mobile Devices for Nervous System Disorders: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      The critical importance of using mobile technology is clear to anyone in the health professions, particularly those who treat people with central nervous system (CNS) disorders. To explore current developments…

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      Multimodal Biomarkers for Central Nervous System Disorders

      National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Forum on Neuroscience and Nervous System Disorders

      A key step towards reducing the burden of central nervous system (CNS) disorders is the identification of disease-specific biomarkers that can help predict, monitor, and guide treatment development. Recent technological…

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      Cover image for Advancing Gene-Targeted Therapies for Central Nervous System Disorders: Proceedings of a Workshop
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      Advancing Gene-Targeted Therapies for Central Nervous System Disorders: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      On April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled Advancing Gene-Targeted Therapies for Central Nervous System Disorders in Washington, DC. This…

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      Cover image for Sharing Clinical Research Data: Workshop Summary
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      Sharing Clinical Research Data: Workshop Summary

      Forum on Drug Discovery, Development, and Translation,Forum on Neuroscience and Nervous System Disorders,National Cancer Policy Forum,Roundtable on Translating Genomic-Based Research on Health,Board on Health Sciences Policy

      Sharing Clinical Research Data: Workshop Summary

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      Cover image for International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary
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      International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary

      National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs

      Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders…

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      Cover image for Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders: Proceedings of a Workshop
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      Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      A report of the National Academies of Sciences, Engineering, Medicine.

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      Cover image for Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood?Brain Barrier: Proceedings of a Workshop
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      Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood?Brain Barrier: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Despite substantial advances in developing treatments for the serious illnesses that affect people worldwide, there remains a tremendous unmet need in the treatment of complex neurologic diseases, including neuropsychiatric and…

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      Cover image for Novel Molecular Targets for Mood Disorders and Psychosis: Proceedings of a Workshop
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      Novel Molecular Targets for Mood Disorders and Psychosis: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Mood disorders - including depression and bipolar disorder - are common, disabling, and potentially lethal disorders, characterized by a shortened lifespan from comorbid medical illness and rising suicide rates. Medications…

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      Cover image for Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop
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      Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Multimodal therapy approaches that combine interventions aimed at different aspects of disease are emerging as potential?and perhaps essential?ways to enhance clinical outcomes for patients with psychiatric and neurological disorders. In…

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      Cover image for Neuroscience Data in the Cloud: Opportunities and Challenges: Proceedings of a Workshop
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      Neuroscience Data in the Cloud: Opportunities and Challenges: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      The cloud model of data sharing has led to a vast increase in the quantity and complexity of data and expanded access to these data, which has attracted many more…

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      Cover image for Neuroscience Trials of the Future: Proceedings of a Workshop
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      Neuroscience Trials of the Future: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to…

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      Cover image for From Molecular Insights to Patient Stratification for Neurological and Psychiatric Disorders
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      From Molecular Insights to Patient Stratification for Neurological and Psychiatric Disorders

      National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Forum on Neuroscience and Nervous System Disorders

      While significant progress has been seen in fields such as cardiovascular medicine and cancer in improving patient stratification and developing targeted drugs based on genetic findings, progress continues to lag…

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      Cover image for Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop
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      Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: a workshop, October 11-12, 2017, Keck Center, Room 100, 500 Fifth Street, NW, Washington, DC –Page 77.

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      Cover image for Sex Differences in Brain Disorders: Emerging Transcriptomic Evidence: Proceedings of a Workshop
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      Sex Differences in Brain Disorders: Emerging Transcriptomic Evidence: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Accumulating evidence gathered over the past three decades has demonstrated a biological basis for differences between men and women with respect to clinical features and treatment responses to several neuropsychiatric…

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      Cover image for Biomarkers of Neuroinflammation: Proceedings of a Workshop
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      Biomarkers of Neuroinflammation: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the…

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      Cover image for Transgenic Neuroscience Research: Exploring the Scientific Opportunities Afforded by New Nonhuman Primate Models: Proceedings of a Workshop
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      Transgenic Neuroscience Research: Exploring the Scientific Opportunities Afforded by New Nonhuman Primate Models: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      To examine the promise, concerns, and challenges related to neuroscience research using genetically modified nonhuman primates, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop on October…

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      Cover image for Exploring Psychedelics and Entactogens as Treatments for Psychiatric Disorders: Proceedings of a Workshop
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      Exploring Psychedelics and Entactogens as Treatments for Psychiatric Disorders: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Psychiatric illnesses - such as major depressive disorder, anxiety disorder, substance use disorder, and posttraumatic stress disorder (PTSD) - are widely prevalent and represent a substantial health burden worldwide. Yet…

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      Cover image for The Role of Nonpharmacological Approaches to Pain Management: Proceedings of a Workshop
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      The Role of Nonpharmacological Approaches to Pain Management: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Board on Health Sciences Policy,Global Forum on Innovation in Health Professional Education

      Pain is a leading cause of disability globally. The dramatic increase in opioid prescriptions within the past decade in the United States has contributed to the opioid epidemic the country…

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      Cover image for Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop
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      Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Health and Medicine Division,Board on Environmental Studies and Toxicology,Board on Health Sciences Policy

      Humans are potentially exposed to more than 80,000 toxic chemicals in the environment, yet their impacts on brain health and disease are not well understood. The sheer number of these…

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      Cover image for Reflections on Sharing Clinical Trial Data: Challenges and a Way Forward: Proceedings of a Workshop
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      Reflections on Sharing Clinical Trial Data: Challenges and a Way Forward: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health

      The workshop participants examine the current state of clinical trial data sharing and reuse and consider ways in which policy, technology, incentives, and governance could be leveraged to further encourage…

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      Cover image for Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting: Proceedings of a Workshop
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      Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health

      Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible…

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      Cover image for Neuroforensics: Exploring the Legal Implications of Emerging Neurotechnologies: Proceedings of a Workshop
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      Neuroforensics: Exploring the Legal Implications of Emerging Neurotechnologies: Proceedings of a Workshop

      National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Technology, and Law,Health and Medicine Division,Board on Health Sciences Policy

      Technological advances in noninvasive neuroimaging, neurophysiology, genome sequencing, and other methods together with rapid progress in computational and statistical methods and data storage have facilitated large-scale collection of human genomic…

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