In 1862 London, the body of a famous surgeon is found, sitting upright, in an old operating theatre. His dead eyes stare at the table at the center of the room, where patients had screamed and cried as medical students looked on. The bookish Inspector Slaughter must discover the killer with the help of his American sergeant Mark Honeycutt and clues from Nightingale nurses, surgeon's dressers, devious apothecaries, and even stage actors. Victorian Southwark becomes the theatre for revealing secrets of the past in a world where anesthesia is new, working-class audiences enjoy Shakespeare, and women reformers solve society's problems.

Murder at Old St. Thomas's is a traditional historical mystery, a book for lovers of Agatha Christie and Anne Perry.