Muhura an evil man because of his anger on god decided to expand his empire in the whole of the universe. He started doing atrocities in the world taking the help of bad angels. But the great psychiatrist Sahamooti and parapsychologist Vamsi demolished the palace in which Muhura and his gang were stationed and made them powerless and helter-skelter for a long time. This is the story of the book 'Amaswitha' written prior to this book and connected to this book. But this book 'Sasikala' can be read and enjoyed without reading the book 'Amaswitha'

But it has been made clear that Muhura, Ahina and the bad angels would only be scattered, incapacitated for some time but they would not be destroyed completely by demolishing the evil palace which was constructed by Sasinadh at the instance of Muhura for him and his bad angels. It has been further made clear, that Muhura and his gang sooner or later could gather together, get their powers back, strike on their betrayers and the world again.

After six months of the demolition of the evil palace, odd and horrifying incidents started to happen again. Aravind's daughter 'Sarita' and psychiatrist Rose's daughter 'Emily' started behaving odd and it has been thought as 'split-personality' for sometime. But as psychiatrists Charles and Niranjan's wives were also behaving oddly, they have to consider the whole of their four behavior in a different angle. Vamsi's inability to contact Amaswitha anymore along with other odd and fearsome incidents also put them in anxiety.

When Sahamooti proposed to make an experiment with the help of Aravind to invite Amaswitha, Aravind agreed to the same. The seance proposed by Sahamooti to invite Amaswitha and talk with her after the failure of the experiment with Aravind, was agreed by each and everyone. How the seance has been conducted, how Vamsi, Sahamooti and Aravind solved the problem of Muhura and his gang forever is the story of this novel 'Sasikala.'