In this follow up to Brain vs Computer: The Challenge of the Century, Jean-Pierre Fillard brings together diverse perspectives to address the recurring theme of rivalry between man and machine.Accelerated by recent events such as the Covid-19 pandemic that caught the world by surprise and brought it to a standstill, the use of technology has become more relevant than ever. What new conclusions can we draw in this debate featuring humans (brain) on the one side, and artificial intelligence (computer) on the other? Featuring brand new content including a complementary perspective from the arts, the author balances the argument from the traditional scientific approach of logic, rationality, and computation with instinct, intuition, and emotion. Read together with his latest offerings Longevity in a 2.0 World and Transhumanism: A Realistic Future? this trilogy culminates in an attempt to answer one of the most exciting questions of our time.