Fear of death and disease preoccupied the European consciousness throughout the early modern era, becoming most acute at times of plague and epidemics. In these times of heightened anxieties, images of saints and protectors served to reassure the faithful of their religious protection against infection. Modes of visual engagement and devotional subject matter were coupled in new ways to reinforce the emotive impact of art works and to reaffirm the perceived reality of the afterlife. In this context, a visual language of mystical devotion, which overcame the limits of the body and even eroticised its suffering, could serve the needs of the desolate and the pained. In this series of essays focused on spiritual sensibilities in Renaissance art and its legacies, authors present original ideas about the themes of death, disease, and mystical experience, based primarily on the study of objects and their documented historical contexts. Methodologically wide-ranging in approach, the resulting volume provides novel insights into the interplay between suffering and art making in the Western world.