This guide is based on the discussions with health care workers, researchers and programme managers from South-East Asia and the Western Pacific Regions and the experiences from scaling-up ART and harm reduction services. The guide is meant to be complementary to the global ART guidelines and are considering the need of physicians, programme planners, other health care workers, People Living with HIV, and drug users to have one simplified user-friendly reference guide for the national adaptation on management of HIV infection and antiretroviral therapy for IDUs