Louis Althusser’s interpretation of Niccolo Machiavelli has never really been studied in any detail as an analysis of political action and intervention. The same is also true for Althusser’s notion of aleatory materialism. Instead, these have conventionally been studied from the viewpoint of a philosophical perspective in which politics is excluded. The objective of the present book thus runs against many of the prevailing views on Althusser. Here the emphasis is placed on Althusser’s advancement of a theory of materialist politics. The main argument put forward is that, for Althusser, it was essential to reflect on how the conjunctural understanding of history and reality could offer a theoretical starting point for a subversive political strategy.