Herbal irrigants refer to solutions derived from natural plant extracts that are used for irrigation in various medical and dental procedures, particularly in oral hygiene and endodontic therapy. These irrigants are often chosen for their perceived antimicrobial, anti-inflammatory, and analgesic properties, as well as their potential to minimize cytotoxicity compared to synthetic alternatives.Herbal medicines are becoming popular and employed in endodontics because they are mostly harmless when used correctly and can be dangerous if overused. Considering that they are beneficial and have few adverse effects, herbs can also be used in endodontic treatment techniques. Safety, ease of accessibility, longer shelf life, economic efficiency, and the absence of microbiological resistance thus far are the main benefits of herbal irrigants. Combining irrigants and using them sequentially will assist to meet all of the requirements for irrigation of the root canal, which will result in successful root canal therapy.