This book delves into a comprehensive exploration of vesiculobullous lesions within the oral cavity, aiming to elucidate their aetiology, pathogenesis, clinical manifestations, and diagnostic challenges. The study investigates the diverse spectrum of vesiculobullous conditions, encompassing diseases like pemphigus vulgaris, bullous pemphigoid, mucous membrane pemphigoid, and others, which often pose diagnostic dilemmas due to overlapping clinical features. Through a meticulous review of existing literature and clinical cases, this research sheds light on the significance of accurate diagnosis and differential diagnosis techniques, including histopathology, direct immunofluorescence, and serological tests. Furthermore, the work explores emerging trends in molecular diagnostics and immunological assays that hold promise for enhancing diagnostic precision in identifying these complex oral lesions. This scholarly work in Lambert Publication contributes valuable insights to the field of oral pathology, guiding clinicians and researchers towards improved strategies for the management and treatment of vesiculobullous lesions in the oral cavity.