Messenger RNA became the focus of research in molecular medicine, as it is a non-toxic molecule that allows transient caprotein expression in virtually all cell types, including dendritic cells. The principles behind nucleic acid vaccines are rooted in Watson and Crick's central dogma - that DNA is transcribed into mRNA, which in turn is translated into protein. The mRNA is synthetically produced and formulated into vaccines. In mRNA vaccine synthesis mRNA transcripts are purified by high performance liquid chromatography (HPLC) to remove contaminants and reactants. mRNAs are translated into corresponding antigens after being inoculated into host cells, imitating virus-infection-like humoral immunity and cellular immunity. By the help of mRNA Vaccine Increasing the antigen reactiveness can be done. the optimized mRNA vaccines should meet the requirement that the innate immunity is fully activated to initiate the adaptive immunity. The first vaccine candidate launched into clinical trials is an mRNA vaccine delivered via lipid nanoparticles. This advantage determines the rapid immune responses after mRNA administration. MRNA vaccine widely for infectious diseases.