In broad terms, the establishment of a scientific and technological agenda is a state management intentionality around which a conflict or difference with society is settled. In this sense, academia is subject to the evaluative guidelines of the quality of its processes and products. As a state-sponsored institution, the public university follows the agenda to the letter, but at the same time, it undertakes the training of talents that the state hopes to institutionalise as leaders of opinion and knowledge. The aim of this paper is to discuss the central axes and themes of the agenda in order to demonstrate the formation of talent through academic entrepreneurship and the incubation of leadership. A documentary study was carried out with a selection of sources indexed in leading Latin American repositories such as Dialnet, Latindex and Redalyc. Lines of research on entrepreneurship in terms of the establishment of the scientific and technological agenda can be seen.