Total Synthesis of Solifenacin, Sitagliptin and novel methodologies

This title is printed to order. This book may have been self-published. If so, we cannot guarantee the quality of the content. In the main most books will have gone through the editing process however some may not. We therefore suggest that you be aware of this before ordering this book. If in doubt check either the author or publisher’s details as we are unable to accept any returns unless they are faulty. Please contact us if you have any questions.

Chiral amines are present in peptides, proteins and many natural products, and they are prevalent in drugs. For these reasons, the development of methods for the synthesis of enantiomerically pure compounds that contain amine functionality has featured prominently in organic synthesis.Many researchers from around the world have contributed innovative and often practicall methods using tert-butanesulfinamide as an extremely versatile reagent for the robust and general asymmetric synthesis of diverse classes of amine-containing compounds. The ready availability of tert butanesulfinamide in large quantities at low cost, the robustness and generality of many of its methods, and the prominence of amine-containing compounds in drugs, agrochemicals, and naturally occurring materials ensures that tertbutanesulfinamide- based methods will continue to be some of the most extensively used methods in the synthesis.