Brain Hypothermia: Pathology, Pharmacology, and Treatment of Severe Brain Injury

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Rapid progress in technology and its application to diagnosis and monitoring of brain tissue temperature and metabolism have resulted in advances in the therapy for critically brain-injured patients and breakthroughs in understanding the pathophysiology of brain damage. The latest concept of brain hypothermia therapy clarifies targets such as brain thermal pooling, masking brain hypoxia associated with catecholamine surge, the metabolic shift from glucose to lipids, and selective radical damage of dopamine in the central nervous system. This volume explains the mechanism of brain injury and how brain hypothermia treatment differs from other hypothermia therapy in four major sections: brain injury mechanism, pathophysiology of hypothermia, basic research of hypothermia treatment, and clinical studies of brain hypothermia. The book hopes to be a valuable source for practitioners and researchers in neurosurgery and neurology and in critical care and emergency medicine.