This volume contains selected papers from the 2021 annual conference affiliated to 'Forum Privatheit', which analyse the current challenges posed by the development of artificial intelligence (AI) to privacy, informational self-determination and democracy, and how they can be addressed through governance mechanisms. The contributions focus on the use of AI for profiling and surveillance purposes, on issues related to the dissemination and detection of disinformation through AI, and on the use of AI in the health and care sectors.