This reprint comprises a compilation of 15 insightful research papers published in the Special Issue "Applied Statistical Modeling and Data Mining" within the Mathematics journal. Spanning multiple domains at the intersection of statistics, machine learning, and real-world applications, the collection presents diverse perspectives and innovative approaches in the field of applied statistical modeling and data mining. These selected papers explore diverse and important topics, including predictive modeling in healthcare, cybersecurity in transportation systems, data quality assessment, emergency call modeling, and innovative crime prevention strategies, among others. By covering a wide spectrum of subjects, this reprint serves as a valuable resource for researchers, academics, and practitioners interested in addressing contemporary challenges across diverse domains through statistical modeling, data mining, and machine learning applications.