The increase we have witnessed in life expectancy in recent years has been a historical milestone in the history of humanity. Nevertheless, this social success presents great clinical and social challenges. After the first successful Special Issue on this topic, the Guest Editors aim to explore different initiatives that result in the health promotion of older adults, such as multicomponent physical exercise programs, interventions that try to avoid loneliness and social isolation and multidisciplinary assessment, and the treatment of frailty and other geriatric syndromes in various settings, such as the emergency unit, orthogeriatrics, and oncogeriatrics. Broadly, this Special Issue is seeking original submissions that examine (1) the method to detect and to reverse frailty and sarcopenia; (2) the method to diagnose early and prevent delirium and other geriatric syndromes; (3) best practices to manage the treatment of the older adults with specific situations, such as hip fracture or oncological disease; (4) best practices for designing, implementing, and/or evaluating integrated interventions to improve healthcare in older adults; and (5) best practices to develop healthcare to improve quality of life in older adults. Special interest will be given to innovative practices that expand and build upon geriatric approaches with multidisciplinary models. Other manuscript types of interest include relevant position papers, meta-analyses, reviews, brief reports, and commentaries.