Urate Deposition in Man and its Clinical Consequences

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One person in four in the industrialized countries suffers from

hyperuricemia and is therefore at risk of developing gouty arthritis,

nephrolithiasis, or any of the other consequences of urate

deposition. At present, far too little is known about urate

deposition and the mechanisms by which it occurs, as well as about

its clinical consequences, which include formation of toph; over the

helix of the ear or in bones close to joints that have never exhibited an
attack, development of bursitis, chronic tendovaginitis leading to carpal
tunnel syndrome, and gouty paraplegia. Information on these matters is

needed to estimate the risks of hyperuricemia and to determine

when therapeutic intervention is indicated. The contributions

and discussions in this book, resulting from an international symposium held in December 1990 in the Medizinische Poliklinik in Munich, provide an up-to-date source of current knowledge about hyperuricemia in man and

its clinical consequences.