Anxiolytic -Carbolines: From Molecular Biology to the Clinic

This title is printed to order. This book may have been self-published. If so, we cannot guarantee the quality of the content. In the main most books will have gone through the editing process however some may not. We therefore suggest that you be aware of this before ordering this book. If in doubt check either the author or publisher’s details as we are unable to accept any returns unless they are faulty. Please contact us if you have any questions.

Since the discovery some 15 years ago of benzodiazepine modulatory sites

associated with GABA A receptors, great effort has gone into understanding their molecular pharmacology and into developing new anxiolytic drugs

that interact selectively with them. Prominent in this research has beenthe discovery that ~-carbolines, a different chemical class from

benzodiazepines, also act at these receptors but that their effects are

sometimes quite different from those of the benzodiazepines.This

book documents the latest discoveries in the molecular biology of the
GABA A receptor and reveals how an integration of the results of research inmolecular biology, synthetic chemistry, biochemical and

behavioral pharmacology, and clinical pharmacology has paved the way forthe development of ~-carbolines from substances inducing anxiety and

convulsions to a novel therapy for anxiety states, achieving a behavioral
selectivity through selective actions at subtypes of receptors.