Risk Assessment of Prenatally-Induced Adverse Health Effects

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Since the thalidomide (Contergan) tragedy about 30 years ago the induction of prenatally-induced morphological or functional defects has been an area of extensive research. Risk assessment of prenatally-induced adverse health effects is still a difficult task from both experimental data as well asfrom observations in humans. In the contributions to this book three major aspects are dealt with: - Quantitative extrapolations of experimental data to the
situation possibly relevant for man. - The significance for a
risk assessment with respect to man
of minor or rare structural

abnormalities observed in
experimental studies - The future need to

assess congenital dysfunctions (e.g. of
the hormone or the immune system) beside the present
evaulation of structural defects. Limitations as

well as gaps of the present knowledge in this area of basic and applied

research are pointed out. Since the results of prenatally-induced lesions
may manifest themselves not only pre- but often not before

late postnatally, numerous aspects of structural and functional abnormaldevelopment must be studied in experimental and clinical investigations.