This volume contains the proceedings of the fifth Colloque Medecine et Re- cherche organized by the Fondation Ipsen pour la Recherche Therapeutique and devoted to Alzheimer’s disease. It was held in Lille on October 16, 1989 and dedicated to imaging, cerebral topography and Alzheimer’s disease. The proceedings of the previous meetings were published as the present one in the same series: Immunology and Alzheimer’s disease (A. Pouplard-Barthelaix, J. Emile, Y. Christen eds.), Genetics in Alzheimer’s disease (P.-M. Sinet, Y. Lamour, Y. Christen eds.) in 1988, Neuronal graJting and Alzheimer’s disease (F. Gage, A. Privat, Y. Christen eds.), Biological markers oJ Alzheimer’s disease (F. Boller, R. Katzman, A. Rascol, J.-L. Signoret, Y. Christen eds.) in 1989. The next meeting of the series entitled growth Jactors and Alzheimer ‘s disease was being held in Strasbourg on April 25, 1990. The proceedings will be published by the end of this year. Yves Christen Vice-President of the Fondation Ipsen pour la Recherche Therapeutique Acknowledgements: The editors wish to express their gratitude to Y. Lamour (Paris), A. Syrota (Paris), J. Clarisse (Lille), F. Boller (Paris), C. Manelfe (Tou- louse) and M. Steinling (Lille) for their collaboration as chairmen for the meeting, Mary Lynn Gage for her editorial assistance and Jacqueline Mervaillie for the organization of the meeting. Contents Topography of Alzheimer’s Disease: Involvement of Assoeiation Neoeortiees and Conneeted Regions; Pathologieal, Metabolie and Cognitive Corre1ations; Relation to Evolution S. I. Rapoport …1 .