Strategizing the disposal and reprocessing of nuclear fuel waste, focusing on plutonium and americium, involves complex considerations. Disposal strategies emphasize deep geological repositories, where waste can be safely isolated for thousands of years, minimizing environmental impact. Reprocessing techniques recover reusable materials from spent fuel, reducing waste volume and extending resource utilization. However, managing plutonium and americium presents challenges due to their long-lived radiotoxicity, requiring stringent containment measures to prevent environmental contamination and public health risks. Innovative approaches such as transmutation aim to transform long-lived isotopes into shorter-lived or stable elements, further reducing the hazardous nature of nuclear waste. International collaboration and regulatory frameworks play crucial roles in ensuring safety and compliance throughout these processes. By integrating these strategies, stakeholders can enhance sustainability, minimize waste volumes, and mitigate the long-term impacts of nuclear fuel waste containing plutonium and americium on both present and future generations.