The intricate mouse brain begins its remarkable journey as a simple neural tube. This hollow tube, formed early in embryonic development, holds the potential for all the brain's future structures. It's within this tube that a specific region, the dorsal portion, takes center stage for the development of the neocortex. The neural tube undergoes a series of transformations. Cells lining the tube, called neural progenitor cells, divide rapidly, generating a pool of precursors. These precursors then embark on a carefully choreographed migration, traveling to their designated locations within the developing brain. In the case of the neocortex, these precursors differentiate into specialized neurons, forming the six distinct layers that become the hallmark of this critical brain region. The neocortex is the crown jewel of the mammalian brain, responsible for higher-order functions like sensory processing, complex thought, and motor control. In mice, while smaller than the human neocortex, it still plays a vital role in behaviors like learning, memory, and navigation. Understanding this journey from neural tube to neocortex in mice provides valuable insights into brain development across mammals. By studying these processes in mice, researchers can unlock secrets of human brain development and potentially shed light on neurological disorders. This knowledge can pave the way for advancements in medicine and a deeper appreciation for the marvels of the brain.