This book is dedicated to the memory of Michael J. Goldstein, one of the pioneers in psychosocial interventions in psychiatry. The structure of this book follows Goldstein’s footsteps in this domain and is subdivided into family factors as well as intervention strategies for severe mental illness. Recent research on high expressed emotion (HEE) in schizophrenia (e.g. , early psychosis) and borderline disorder, patients’ perspectives of HEE as well as other variables predictive for relapse in recent-onset schizophrenia are covered in this book. Family treatment strategies in schizophrenia, depression, bipolar disorder, substance use disorders and illness management programs as well as pharmacological treatment strategies are illustrated and current studies presented. The book brings together basic research and therapeutic applications stimulating further research on the complex interactional components that influence the course of psychiatric illness and on treatment designed to ameliorate the symptoms, stigma, and disability experienced by patients with severe mental illness.