This reprint includes 23 research articles and 1 review accepted and published by MDPI in the Special Issue entitled "Recent Advances and Applications in Partial Least Squares Structural Equation Modeling (PLS-SEM)", comprising 7 articles in Economies, 6 articles in Mathematics, 10 articles in Sustainability and 1 article in Data. The covered topics include the impacts of COVID-19 and climate change on food security or the tourism sector, the critical factors affecting the implementation of corporate governance, consumers' perspectives and behaviors toward corporate social responsibility, consumers' ethnocentrism and country of origin, the differentiation strategy and export performance in emerging countries, the influence of agricultural development on alleviating rural poverty, leadership and employee performance, the relationship between entrepreneurial orientation and business performance, the role of commitment in an extended theory of planned behavior, major shifts in sustainable consumer behavior, an empirical evaluation of customers' adoption of drone food delivery services, European citizens' happiness, the mediation of corporate social responsibility between information and communication technologies adoption and SMEs performance, students' satisfaction about blended learning, etc. This reprint is expected to benefit those working in the area of PLS-SEM, regardless of their field of study (economics, finance, marketing, education, etc.). Applications involving higher-order constructs, mediating variables, multigroup analysis, and the latest advances in applied methodology are detailed in this reprint.