This reprint is a collection of papers from the E-Textiles 2021 Conference and represents the state-of-the-art from both academia and industry in the development of smart fabrics that incorporate electronic and sensing functionality. The reprint presents a wide range of applications of the technology including wearable textile devices for healthcare applications such as respiratory monitoring and functional electrical stimulation. Manufacturing approaches include printed smart materials, knitted e-textiles and flexible electronic circuit assembly within fabrics and garments. E-textile sustainability, a key future requirement for the technology, is also considered. Supplying power is a constant challenge for all wireless wearable technologies and the collection includes papers on triboelectric energy harvesting and textile-based water-activated batteries. Finally, the application of textiles antennas in both sensing and 5G wireless communications is demonstrated, where different antenna designs and their response to stimuli are presented.