Heat Shock Proteins and Inflammation

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Heat shock proteins (HSP) have received ample interest by immunologists
over recent years. Initially they were found to be dominantly
immunogenic microbial antigens. The connection with inflammation was
established when it was uncovered that T cells specific for these
antigens have a crucial role in the induction and regulation of
experimental arthritis. Since then, the raised presence of immunity to
HSPs in virtually all conditions of inflammation, including autoimmune
diseases, transplant rejection and atherosclerosis, has emphasised the
critical significance of immunity to HSPs in inflammatory diseases.