This book investigates new important applications of the Spatial Grasp Technology (SGT) allowing us to effectively simulate and manage large distributed dynamic systems on semantic and holistic levels. This patented technology, developed for decades and in different countries, is based on a completely different philosophy and model allowing us to directly operate in united distributed physical and virtual spaces and provide system solutions much simpler and more compact than under other approaches. The described applications include basic operations suitable for solving many network-related problems, simulation of such mysterious concept as consciousness so important for the design of advanced intelligent systems, modelling the spread of viruses and distribution of antivirus vaccine, and also implementation of the latest decision-centric and mosaic-based organizational concepts important for modern defence and industrial systems. The described technology version with its Spatial Grasp Language can be implemented even within university environments, with communicating language interpreter copies, potentially numbering millions to billions, easily embedded into any existing systems, including Internet, thus converting the whole world into a powerful symbiotic simulation management engine. The book is oriented on system scientists, application programmers, industry managers, and also university students interested in advanced M.Sc. and Ph.D. projects related to distributed system management.