This book deals with numerical simulations and computations of the turbulent flow around high-lift configurations commonly used in aircraft. It is devoted to the Computational Fluids Dynamics (CFD) method using full Navier-Stokes solvers typically used in the simulation of high-lift configuration. With the increase of computational resources in the aeronautical industry, the computation of complex flows such as the aerodynamics of high-lift configurations has become an active field not only in academic but also in industrial environments. The scope of the book includes applications and topics of interest related to the simulation of high-lift configurations such as: lift and drag prediction, unsteady aerodynamics, low Reynolds effects, high performance computing, turbulence modelling, flow feature visualization, among others. This book gives a description of the state-of-the-art of computational models for simulation of high-lift configurations. It also shows and discusses numerical results and validation of these computational models. Finally, this book is a good reference for graduate students and researchers interested in the field of simulation of high-lift configurations.