The chapters in this volume, and the volume itself, celebrate the life and research of Roberto Tempo, a leader in the study of complex networked systems, their analysis and control under uncertainty, and robust designs. Contributors include authorities on uncertainty in systems, robustness, networked and network systems, social networks, distributed and randomized algorithms, and multi-agent systems-all fields that Roberto Tempo made vital contributions to. Additionally, at least one author of each chapter was a research collaborator of Roberto Tempo’s. This volume is structured in three parts. The first covers robustness and includes topics like time-invariant uncertainties, robust static output feedback design, and the uncertainty quartet. The second part is focused on randomization and probabilistic methods, which covers topics such as compressive sensing, and stochastic optimization. Finally, the third part deals with distributed systems and algorithms, and explores matters involving mathematical sociology, fault diagnoses, and PageRank computation. Each chapter presents exposition, provides new results, and identifies fruitful future directions in research. This book will serve as a valuable reference volume to researchers interested in uncertainty, complexity, robustness, optimization, algorithms, and networked systems.