The total synthesis of natural products has been a challenging and rewarding field in organic chemistry, with potential applications in drug discovery and development. In particular, the total synthesis of Solomonamides, a group of bioactive compounds with potent anti-inflammatory properties and antifungal activity, has attracted the attention of researchers worldwide. Author is one of the leading experts in this area, having contributed significantly to the understanding of the design, synthesis, and biological evaluation of Solomonamides and related antifungal agents. Solomonamides are complex molecules that are isolated from a marine sponge. They contain a unique silicon atom and a morpholine ring, which are crucial for their bioactivity. Overall, the work of author in the total synthesis of Solomonamides and related antifungal agents has contributed significantly to the understanding of organic chemistry, drug discovery, and development. His work has demonstrated the potential of these compounds in treating fungal infections and inflammatory diseases, and has opened up new avenues for the development of synthetic analogs with improved pharmacological properties and therapeutic potential.