The Educational Leader’s Guide to Improvement Science: Data, Design and Cases for Reflection is a collection of edited chapters illustrating applied organizational problem-solving using methods of Improvement Science in educational leadership. Early chapters introduce Improvement Science, along with an overview, rationale, and challenges for exploring this emerging field. The reader is led through a logical sequence of inquiry, presented with cases of educational dilemma matched with principles of improvement science and provided examples of research methodology applied in context. Because Improvement Science research is so quickly becoming a signature pedagogy and core subject area of inquiry in the field of educational leadership, the literature is scant in its coverage of improvement science models; it is the purpose of this publication to fill the void by providing concrete examples, through case studies, of instances where improvement research methods and analyses can be embedded to enhance and strengthen efforts at organizational improvement. This text concentrates on the elements faculty, students, and administrators need; specific models where improvement science frameworks enhance the reliability and validity of improvement or quality enhancement efforts.