This is the 3rd in a series of reviews, centered on a single major topic (vol. 1 Bone Formation, vol. 2 Bone Resorption) written by acknowledged authorities in the field. All chapters include recent technological advances - bioinformatics related to completion of the human genome project, screening technologies, microarray technologies, new transgenic animal models, computer assisted imaging technologies, and computer/mathematical analyses.Like other texts in this series, this volume is designed to integrate current information, in this instance technological and engineering advances, with new knowledge gained from tissue, cellular and molecular studies of the skeletal system. It therefore will interest bioengineers, orthopedists, physiotherapists, reconstructive surgeons, and all concerned with skeletal function and rehabilitation.