These volumes chronicle the outbreak and world-wide spread of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures. Designing safe and effective antiviral drugs are extremely challenging, the drug or chemical must interfere with the virus life cycle without harming the host organism’s cells or systems. Viral variation and mutation is another major difficulty in developing and applying appropriate vaccines, antiviral drugs and interventions. By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, these books document and highlight the advances in science and place the toxicology, pharmaceutical science, public health and medical community in a better position to advise in future epidemics.