In 2150 a catastrophic war led to 70% of Britain's population being wiped out. Strontium 90 fallout led to an increase of children being born with strange mutations. Hated by average humans, the mutants faced terrible oppression when politician, Nelson Kreelman, introduced a series of anti-mutant laws enforced by a brutal police force.

In 2167 the mutants decided to fight back. Amongst their ranks was a young boy with named Johnny Alpha with white blank eyes and a mutant power that grants him a series of powers, including the ability to see through many surfaces. Driven by tragedy, Johnny has a very personal reason wanting to topple the regime and bring Kreeler down.

Co-written by Alan Grant (Batman)and John Wagner (A History of Violence) and featuring the artwork of Carlos Ezquerra (Judge Dredd), this collection features the explosive origin of Johnny Alpha in 'Portrait of a Mutant', a tale widely considered to be the greatest Strontium Dog story of all.