Assessment of Drug Interactions & Drugs Resulting in QT Interval Prolongation

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QT interval is estimated from the beginning of Q wave to the end of T wave on ECG. This can be explained due to the shortening or lengthening of the ventricular repolarization. The study has performed to assess QT interval prolongation due to drugs and drug-drug interactions resulting QT interval prolongation. This study reveals some of the specific drugs causing QT interval prolongation. The study also reveals that QT interval prolongation occurs in almost all therapeutic classes of drugs (like tricyclic antidepressants, anti-emetics, prokinetic agents, antifungals, cardiovascular drugs etc) among which cardiac drugs were majorly causing the prolongation. This research work founded five major causes that lead to QT interval prolongation. The study also discusses about risk factors which are considered as a causative factor to prolong QT interval.