A History of the United States through High-Profile Assassinations presents a unique perspective on American history, framing the narrative through a sequence of notable assassinations and attempted assassinations. This approach offers a novel lens through which to examine historical continuity and change. The text emphasizes the broader social, political, and historical contexts revealed by these violent acts, regardless of whether the perpetrators aimed to make a political statement.

The book explores the evolution of the term "assassination," its historical roots, and its impact on social and political change globally and within the United States. It delves into typologies of assassins, uses various historical episodes to discuss broader issues, and includes less explored assassination attempts alongside well-known events. Additionally, the book pays attention to the narratives often relegated to the sidelines of history, reflecting on the experiences of ethnic minorities and women.

A History of the United States through High-Profile Assassinations serves as a compelling primary or supplemental text for courses in American history, criminal justice, and political science. It provides an innovative approach to learning that encourages students to connect individual events with larger national and international trends.