The Reinvention of Social Practices shows the relevance of Felix Guattari’s thought for the analysis of contemporary social and cultural encounters, ranging across an alternative ‘skateboard’ school, informatic subjugations, urban ecological dilemmas, drug subcultures, and countercultures. Gary Genosko, the leading English interpreter of Guattari, expands upon Guattari’s conception of schizoanalysis as a transformative process of critical self-modelling that leads to the creation of new maps of existence, highlighting an interpretive dream pragmatics, a peripatetic psychiatric practice, a rethinking of epilepsy, and a post-media vision of digital interfaces beyond the keyboard. The folds of Guattari’s collaborations with Gilles Deleuze and Antonio Negri are explored, and his philosophical friendship with Franco Bifo Berardi is brought into focus.