Blasphemy and Other Ancestors is comprised of four novellas, in which authors Padgett Powell, Darius James, Lee Henderson, and Jean Marc Ah-Sen explore the tag end of existence and the abasements that memory holds in store for characters living "outside of their time."

In Blasphemy and Other Ancestors, a Southern man of letters tries to instruct his assistant on the matters of the heart, a self-centered telephile recounts how his aunt taught him about the world beyond his T.V. set, an avant-garde filmmaker is haunted by a Nazi persecutor at the 1974 Cannes Film Festival, and a sundowner discovers that a writer recording the events of his life holds the secret to his ability to remember his past lives.