When the most recent outbreak of human vampirism occurred in the narrow oasis of New Mexico's lower Rio Grande Valley, the terrifying oral tradition that had been passed on for more than four centuries had yet again been sadly reconfirmed. Every two decades or so, one or more bloodthirsty ghouls would appear that would prey upon the unsuspecting and completely vulnerable members of New Mexico's small but harmonious and tightly knit community that had long been an admixture of First American, Hispanic, and Anglo residents.

As a young curandera, Lorena Pastore was only twenty-five years old when the last outbreak occurred, and she remembered the devastation and shocking horror that had rapidly spread throughout her beloved community at that time. She had erroneously predicted that she would be well into her middle years of life when the next outbreak would be anticipated to once again rear its ugly head. Sadly, that was not to be the case. For some inexplicable reason, after only a brief remission of a little more than a seven-year hiatus, the malignant disease of human vampirism had been reincarnated. This time, the Vampiro outbreak was destined to appear on Lorena Pastore's very own doorstep.