When a Navajo teen is searching for lost treasures on a plateau north of Chaco Canyon, he discovers an artifact that infects him with the virus responsible for human vampirism. A team of archaeologists investigates the circumstances of what occurred, and unfortunately, the Navajo scientist, Dr. Zachary Hawk, becomes infected with the deadly malady. To escape the wrath of the government's Night Crawler Protocol, Hawk and a colleague flee to Mexico to avoid a sanctioned execution. When Hawk undergoes a violent transformation to become a human vampire, he joins forces with a band of ruthless children afflicted with the same disease who are terrorizing the community of Santa Sangre.

Blake Barker continues his quest to find his kidnapped child in Mexico and Blake garnishes the hostility of the Mexican drug cartel seeking to capture a vampire for their nefarious purposes. Sadly, Blake contracts a life-threatening malignancy which may lead to his premature demise. Will Blake ever find his missing son?