In a suffering world reeling from global pandemics and health disparities, it is high time to think theologically about the devastating experience of disease, and to address our God-inspired responsibility to understand its origins and engage in its management. In a fragmented world, we need a unifying and integrated perspective on people in communities embedded in a fractured ecology. In an academic world blind to the spiritual world and imbalanced toward technical solutions, the global church must articulate a contemporary metanarrative that is moral, practical, and deeply transformational. All Creation Groans brings together multiple perspectives for a compelling global-health approach to the pathologies of the world as a part of the missio Dei. The authors paint a unifying perspective on God’s healing intentions in creation, redemption, and consummation, and the opposing nature-corrupting effects of the rebellion of created moral agents. It is a fresh call for the global church to engage in aligning with God’s healing action for eternally sustainable global health.