Could a father sacrifice his daughters to save humanity? Seven years after a man-made biological disaster kills every fertile woman on Earth, the new global government kidnaps the surviving pre-pubescent girls, forcibly locking them away in sanctuaries to "keep them safe" from fathers that would sterilize them to save their lives. Artemis E is one such sanctuary, protected by an armed militia known as Guardians, and staffed by Novas, women who survived the disaster due to infertility. Former police chief Asher Drake joins the Guardians to be close to his two young daughters, who are imprisoned there. He discovers that Artemis E has a stowaway fugitive, his former lover, Suri Sinha, who may be the only fertile woman left alive Reunited after many years, Asher must now protect Suri from everyone who is hunting for her: the desperate men who want to use her, the lost boys that want to love her, and the scientists that want to experiment on her. Meanwhile, Asher learns that his daughters are not as safe at Artemis E as he believed, and that the government has secret plans for their future. Suri and Asher must learn to trust each other again to save them all, and the world.