An examination of the dual Scottish-Yamasee colonization of Port RoyalThose interested in the early colonial history of South Carolina and the southeastern borderlands will find much to discover in Carolina’s Lost Colony in which historian Peter N. Moore examines the dual colonization of Port Royal at the end of the seventeenth century. From the east came Scottish Covenanters, who established the small outpost of Stuarts Town. Meanwhile, the Yamasee arrived from the south and west. These European and Indigenous colonizers made common cause as they sought to rival the English settlement of Charles Town to the north and the Spanish settlement of St. Augustine to the south. Also present were smaller Indigenous communities that had long populated the Atlantic sea islands. It is a global story whose particulars played out along a small piece of the Carolina coast. Religious idealism and commercial realities came to a head as the Scottish settlers made informal alliances with the Yamasee and helped to reinvigorate the Indian slave trade-setting in motion a series of events that transformed the region into a powder keg of colonial ambitions, unleashing a chain of hostilities, realignments, displacement, and destruction that forever altered the region.