Ex-FBI profiler River Ryland still suffers from PTSD after a case went horribly wrong. Needing a fresh start, she moves to St. Louis to be near her ailing mother and opens a private investigation firm with her friend and former FBI partner, Tony St. Clair. They're soon approached by a grieving mother who wants them to find out what happened to her teenaged son, who disappeared four years ago. River knows there's almost no hope the boy is still alive, but his mother needs closure, and River and Tony need a case, no matter how cold it might be.