Angiogenesis in Health and Disease

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Angiogenesis is the physiological process of the generation of new blood vessels from pre-existing vessels that were formed during vasculogenesis. By sprouting and splitting, angiogenesis perpetuates the growth of the vasculature. It is a vital process in growth and development, as well as in the formation of granulation tissue and wound healing. However, it has a major role in the transition of benign tumors into malignant ones. Some diseases are characterized by abnormal vasculature. Therefore, such diseases are combated by inhibiting or inducing the creation of new blood vessels. The principle of angiogenesis can be applied clinically in two main areas- anti-angiogenic therapies and pro-angiogenic therapies. Anti-angiogenic therapies are employed to fight cancer and other malignancies, while pro-angiogenic therapies are potent against cardiovascular diseases. This book includes some of the vital pieces of work being conducted across the world, on various topics related to the role of angiogenesis in health and disease. It presents the complex subject of angiogenesis in the most comprehensible and easy to understand language. It is meant for students who are looking for an elaborate reference text on angiogenesis.