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Sarcomas are rare tumors arising from transformed cells of mesenchymal origin. These tumors occur more commonly in the bones and muscles, cartilage, tendons, nerves, fat and blood vessels of the limbs. These can however occur in other areas of the body as well. More than 50 types of sarcoma exist, which can be categorized under bone sarcoma (osteosarcoma) and soft tissue sarcoma. The susceptibility to sarcoma depends on a number of factors, such as family history of sarcoma, Paget's disease, genetic disorders such as Gardner syndrome, Li-Fraumeni syndrome, neurofibromatosis or retinoblastoma. Soft tissue sarcomas can grow anywhere in the body and may be difficult to detect. Osteosarcoma is comparatively easier to diagnose and presents symptoms such as swelling, pain in the affected bone and a limp. The treatment of sarcoma depends on the type of sarcoma, its location, and the extent of growth and metastasis. Surgery, chemotherapy, targeted therapies and radiation are the primary treatments for the management of sarcomas. This book is compiled in such a manner, that it will provide in-depth knowledge about the diagnosis and treatment of sarcoma. It is a valuable compilation of topics, ranging from the basic to the most complex advancements in oncology. It aims to serve as a resource guide for students and experts alike and contribute to the growth of the discipline.
