Neurodegeneration: Contemporary Neuroscience

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Neurodegeneration is a condition characterized by progressive structural and functional loss of neurons. It is a basic feature of neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease. Many parallels exist between such disorders such as induced cell death and atypical protein assemblies. Alzheimer's disease involves a loss of neurons and synapses in certain subcortical regions and in the cerebral cortex. Huntington's disease causes a loss of medium spiny neurons and astrogliosis. There are no medical strategies to reverse such degeneration. Much research is being done to explore the therapeutic effects of protein degradation and autophagy upregulation, as well as passive and active vaccinations against neurodegeneration. This book includes some of the vital pieces of work being conducted across the world, on various topics related to neurodegeneration. The various aspects of neuroscience along with clinical progress that have future implications in the understanding and management of neurodegeneration are glanced at in this book. It is appropriate for students seeking detailed information in this area as well as for experts.