Colorectal cancer (CRC) is the world’s third most common cancer. The symptoms and syndromes most commonly observed in CRC patients are pain, nausea/vomiting, weight loss, fatigue, constipation/diarrhoea, gastrointestinal bleeding, bowel obstruction and confusion. Both locally advanced tumours and its distant metastasis can lead to extreme discomfort. Palliative care in oncology focuses on prevention and relief of suffering to optimise quality of life. Also discussed in this book is the psychosocial studies of colorectal patients in China where this type of cancer has the sharpest increase in incidence and mortality.