Victoria Jackson revolutionized the beauty industry in the 1980s and '90s with her "no make-up" approach to make-up and ultimately made Victoria Jackson Cosmetics into a billion-dollar global brand. But her greatest test of the power of rare didn't come until her daughter, Ali,was diagnosed with neuromyelitis optica, or NMO-a rare, life-threatening autoimmune disease-and Victoria, driven by a mother's love, set out to find a cure for her daughter.

Within days of hearing Ali's diagnosis in 2008, Victoria began the Guthy-Jackson Charitable Foundation to fund medical research into this often misdiagnosed orphan disease. Her "blueprint" called for breaking down the so-called silos of traditional medical research and bringing together some of the greatest minds to collaborate and share their findings. She hadn't expected to galvanize how medical research works, but within only a few years, that's just what she did. By focusing on the "rare" in each of us, the foundation has catalyzed breakthroughs in NMO in record time. These advances are also opening new doors to solving MS, lupus, and other autoimmune diseases-plus diseases that are not so rare, including cancer, infection, aging, and more.

she shares how the foundation harnessed the power of rare to speed discoveries that help patients. Through her business savvy, wit, and heart, she offers real-world advice and inspiration for others to tap into "rare" to empower their own breakthroughs.