Stem Cell Basis of Cancer: Tumorigenesis and Drug Development

It is a widely accepted paradigm in oncology that stem cells are the cells of origin of most, if not all, malignancies. Discoveries of mechanisms unique to stem cells will serve as molecular targets for new drug development and lead to new, more effective approaches to cancer therapy and chemoprevention. Stem Cell Basis of Cancer: Tumorigenesis and Drug Development makes available the current knowledge in the field, including concepts in tumoregenesis that involve stem cells in not only hematopoietic malignancies but solid tumors (including colon, lung, breast, and prostate). This book also addresses hereditary cancer syndromes as well as stem cells in novel therapeutic and chemopreventive approaches.